Effect of space flight on interferon production mechanistic studies : final report by Gerald Sonnenfeld

Cover of: Effect of space flight on interferon production | Gerald Sonnenfeld

Published by National Aeronautics and Space Administration, National Technical Information Service, distributor in [Washington, DC, Springfield, Va .

Written in English

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  • Interferon.,
  • Space flight.

Edition Notes

Book details

StatementGerald Sonnenfeld, principal investigator.
SeriesNASA contractor report -- NASA CR-188972.
ContributionsUnited States. National Aeronautics and Space Administration.
The Physical Object
Pagination1 v.
ID Numbers
Open LibraryOL15369705M

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EFFECT OF SPACE FLIGHT ON INTERFERON PRODUCTION STUDIES MECHANISTIC Gerald Sonnenfeld, Ph.D. - Principal Investigator* Department of Microbiology and Immunology School of Medicine University of Louisville Louisville, KY ; *The NASA Technical Monitor for this grant is: Dr.

Gerald R. Taylor Mail Code SD-5 NASA Johnson Space Center Houston. Get this from a library. Effect of space flight on interferon production book Effect of space flight on interferon production: mechanistic studies: final report.

[Gerald Sonnenfeld; United States. National Aeronautics and Space Effect of space flight on interferon production book. Later studies by Konstantinova and her associates have found alterations in interferon-cx, interferon-y, and interleukin-2 production of cells obtained from Cosmonauts after long-term space flight.

Therefore, long-term space flight could have drastic effects on the cytokine system.7 CONCLUSIONS There can be little doubt that space flight has Cited by: Interferon-γ production was inhibited dramatically in the cultures. 33 Production of another cytokine in the same cultures, interleukin-3, was not affected by exposure to space flight conditions.

33 Therefore, exposure to space flight produces different effects on different components of the immune by: Interferon-γ (IFN-γ) is a pleiotropic cytokine with antiproliferative and immunomodulatory activities that are crucial for the regulation of immune responses.

We examined a group of military pilots. The examinees were divided into 3 subgroups: ground personnel (9 persons, control group), 17 pilots with h flight : Elena Arkhipova, Irina Alchinova, Mikhail Karganov. Atherton KT, Burke DC.

Interferon induction by viruses and polynucleotides: a differential effect of comptothecin. J Gen Virol. Dec; 29 (3)– [Google Scholar] Billiau A, Edy VG, Heremans H, Van Damme J, Desmyter J, Georgiades JA, De Somer P.

Human interferon: mass production in a newly established cell line, MGCited by: Effect of antiorthostatic suspension on interferon-alpha/beta production by the mouse.

Rose A, Steffen JM, Musacchia XJ, Mandel AD, Sonnenfeld G. Mice were suspended in a model that simulates weightlessness that occurs during prolonged space by: Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS).

It is produced by mammalian cells, while interferon beta-1b is produced in modified E. coli. Some claims have been made that Interferons produce about an 18–38% reduction in the rate of MS status: US: ℞-only. production of alpha interferon by macrophages and lymphocytes. The first interferon ever discovered is the beta type, which was first observed by Isaacs and Lindenmann.

It used to be called ‘fibroblast interferon’ because it is produced by epithelial cells and fibroblasts under the action of foreign nucleic acids like viruses or other types. Effects of the Space Flight Environment on the Immune System Effects of the Space Flight Environment on the Immune System Sonnenfeld, Gerald; Butel, Janet S.; Shearer, William T.

R E V I E W S ON E N V I R O N M E N T A L H E A L T H V O L U M E 18, NO. 1, Gerald Sonnenfeld, 1 Janet S. Butel, 2 and William T. Interferon-a (a family of about 20 related proteins) and interferon-b are particularly potent as antiviral agents. They are not expressed in normal cells, but viral infection of a cell causes interferons to be made and released from the cell (that cell will often eventually die as a.

by Zhenya Senyak The Interferon Papers Part III. Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis The final word on interferon and MPN treatment comes from the three men who share the deepest clinical experience in applying a molecule derived from the cell's own defenses to roll back the effects of myeloproliferative.

These results suggest that interferon-induced mechanisms which inhibit influenza virus replication in MDBK cells act at the level of primary transcription. Figures - uploaded by Richard M. In fact, interferon beta is antagonistic to the effects of interferon gamma and, as they later found, this reduces the autoimmune process in multiple sclerosis.

Inhaving isolated the human gene encoding interferon beta, Revel's group searched for an efficient method to produce the substance in quantity. The immune stimulatory effects are of particular importance to space-flight, since there has been documented evidence of viral reactivation and decreased T-cell activity during spaceflight (Cohrs ; Crucian ; Pierson ).

Probiotics are available for human consumption as a dietary supplement, within foods as. Applies to interferon alfa-2a: injectable powder for injection, injectable solution. Psychiatric. Psychiatric side effects have included depression (16% to 28%) and suicidal behavior including suicidal ideation, suicide attempts, and suicides.

Irritability (15%), insomnia (14%), anxiety (5% to 6%), and behavioral disturbances (3%) have also been reported. In a study of. PDF | Interferon (IFN)-gamma reduces airway responses after allergen challenge in mice. The mechanisms of this effect are not clear. These studies | Find, read and cite all.

Bini EJ, Weinshel EH "Severe exacerbation of asthma: A new side effect of interferon-alpha in patients with asthma and chronic hepatitis C." Mayo Clin Proc 74 (): Hejny C, Sternberg P, Lawson DH, Greiner K, Aaberg TM "Retinopathy associated with high-dose interferon alfa-2b therapy." Am J Ophthalmol (): / Reduced interferon-γ (IFN-γ) production in suspended mice has been correlated to increased susceptibility to viral infection similar to that observed in rats flown on the US Space Shuttle.

Therefore, there is an increased risk of infections among crewmembers during spaceflight resulting from working and living in a crowded, closed environment Author: Anil D Kulkarni, Marie-Francoise Doursout, Asmita Kulkarni, Alamelu Sundaresan, Takehito Miura, Koji.

Interferons (IFNs) are a family of glycoproteins that are naturally secreted by certain cells in response to viral infection. The naturally occurring IFNs confer protection on other cells, preventing them from becoming infected, a phenomenon referred to as "virus interference" by Isaacs and Lindenmann 1 in the first description of these proteins.

In addition to their Cited by: the effects of space flight conditions on the immune system. In order to provide this information, opportunities for ground-based modeling and spaceflight experiments designed to compare effects of sex differences in spaceflight conditions on.

How Space Travel Can Damage Our Immune Systems working to understand just what effects long-term space flight has on the human body. And the more closely we look at. At long last, the first book to cover all important areas of interferon science in one volume.

Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications.

Edited by an experienced interferonologist. Interferon is a substance produced by the body's white cells to fight infections, cancer, allergies and toxic chemical poisoning. Interferon can be made artificially and injected for some cancers and viral infections like hepatitis C.

Studies indicate that many natural substances can activate the body's own production of interferon. n/a Ensembl ENSG n/a UniProt P n/a RefSeq (mRNA) NM_ n/a RefSeq (protein) NP_ n/a Location (UCSC) Chr 9: – Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon alpha-1/13 is a protein that in humans is encoded by the IFNA1 gene.

Leukocyte interferon is produced predominantly by B lymphocytes. Immune Aliases: IFNA1, IFL, IFN, IFN-ALPHA, IFN-alphaD. Hardware. Hardware Search. Hardware Type Version Title.

Mission. Payload Johnson Space Center Interferon alphas are used to treat leukemia, melanoma, non-Hodgkin's lymphoma, Kaposi's Sarcoma, hepatitis C, hepatitis B, and HPV. They work by helping the body fight the infections. Kaposi's Sarcoma (8%) Non-Hodgkin's Lymphoma (8%) How is this chart calculated.

This chart is created by aggregating the total number of claims for the drugs in. What this intends, is that the cell continuously produces interferon at low level. In effect, the regulatory system which supresses the production of interferon except when induced by viruses or dsRNA, has been at least partially inactivated so that the interferon gene is continuously transcribed to produce mRNA, which is then translated to.

production by specific human peripheral blood cell subsets immediately following space flight. Journal of Interferon and Cytokine Research 20(6), December A scanning electron micrograph of a human T lymphocyte.

For additional information, contact: Office of Biological and Physical Research, National Aeronautics and Space. The infecting virus also induces the host cell to produce interferon mRNA (IFN-mRNA), which is translated into alpha and beta interferons 4.

Interferons released by the virus-infected host cell bind to plasma membrane or nuclear membrane receptors on uninfected neighboring host cells, inducing them to synthesize AVPs.

Step Operation Volume [L] Interferon [g] Activity [U/L] Specific Activity Percent Yield Purification Factor Processing Times [hours] 1 Cell Lysis 1 98 % 1 70 2 Guanidine/HCl Extraction 4 96 % 4 5 3 Nickel-ion Chelate Absorbent (Chromatography) 94 % 4 Gel Filtration in 7M Urea These results were originally reported with data obtained from astronauts during relatively short-term space shuttle flight 69 but have been extended to longer-term Mir space station experiments.

70 Effect of isolation on interferon production and hematological parameters. Interferon Res. The National Academies Press. doi. Start studying Ch 17 micro. Learn vocabulary, terms, and more with flashcards, games, and other study tools.

Search. What is the effect of alpha interferon on an uninfected cell. Antigenic stimulation of a particular B cell that results in the production of a large number of plasma and memory cells, all capable of responding to that. Interferon, any of several related proteins that are produced by the body’s cells as a defensive response to viruses.

They are important modulators of the immune response. Interferon was named for its ability to interfere with viral proliferation. The various forms of. Other articles where Alpha interferon is discussed: therapeutics: Biological response modifiers: Interferon-α is produced by a recombinant DNA process using genetically engineered Escherichia coli.

Recombinant interferon-α appears to be most effective against hairy-cell leukemia and chronic myelogenous leukemia, lymphoma, multiple myeloma, AIDS-associated Kaposi. seemed optimal for the interferon production.

By using our new protocol, we recovered approximately mg of IFNα-2a with a specific activity of × IU/mg from 20 l of the broth. The gel permeation chromatographic and SDS-PAGE indicated that the interferon preparation was purified to homogeneity and was of the correctly folded fast.

Interferon is a term given to several types of protein found naturally in the human body. These proteins work to boost the immune system by interfering with the ability of a virus to reproduce. DNA technology has provided a means for these naturally occurring proteins to be used in the development of prescription medications aimed at curing or relieving symptoms of.

Friedman RM, Ramseur JM () Inhibition of murine leukemia virus production in chronically infected AKR cells: a novel effect of interferon. Proc Natl Acad Sci Cited by: The mechanism of interferon production BY D.

BURKE Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, U.K. Interferons are formed when most cells are treated with viruses or double-stranded RNA (to form IFN-cL or f, or both) or when lymphoid cells are treated with mitogens or the appropriate antigen (to form IFN-,y).

Sonnenfeld G, Gould CL, Williams J, Mandel AD () Inhibited interferon production after space flight. Acta Microbiol Hung 35(4)– PubMed Google Scholar Sonnenfeld G, Davis S, Taylor GR, Mandel AD, Konstantinova IV, Lesnyak A et al () Effect of space flight on cytokine production and other immunologic parameters of rhesus : Brian Crucian, Clarence Sams.

Ishihara, T. et al. Inhibition of Chlamydia trachomatis growth by human interferon-α: mechanisms and synergistic effect with interferon-γ and tumor necrosis factor-α.

Cited by: Interferon. Interferon is used for the treatment of active Hepatitis B and C, HIV/AIDs and Multiple Sclerosis. Interferon is widely documented to have a large number of side-effects. The majority of these side-effects are incompatible with safely undertaking flight duties.

The endocrine system coordinates with the nervous system to control the functions of the other organ systems. Cells of the endocrine system produce molecular signals called hormones. These cells may compose endocrine glands, may be tissues or may be located in organs or tissues that have functions in addition to hormone : Charles Molnar, Jane Gair, Molnar, Charles, Gair, Jane.

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